|Molecular Biomedicine Latest Research
|New AUC published for lumbar puncture and spinal fluid analysis in Alzheimer's diagnosis|
Alzheimer's disease is commonly diagnosed by a thorough examination of
physical health, medical history and assessment of memory, thinking and
reasoning. Lumbar puncture, while not currently in routine clinical practice in
the U.S., is anticipated to be a safe and cost-effective way to retrieve
cerebrospinal fluid (CSF) to test for biological markers of Alzheimer's
disease, potentially delivering valuable diagnostic information to clinicians
and their patients earlier in the course of the disease
Appropriate uses of lumbar puncture:
- A
patient has subjective cognitive decline (SCD) and is considered to be at
an increased risk for Alzheimer's disease based on indicators that include
a persistent decline in memory, younger onset age (>60), onset in the
last 5 years and others. The decision to perform CSF biomarker testing in
this case should be individualized and most strongly supported when the
individual, family and clinician all are concerned about the patient's
cognitive decline.
- A
patient has mild cognitive impairment (MCI) that is persistent,
progressive and unexplained. MCI includes mild deficits on cognitive
testing but no change in functional abilities.
- A
patient has symptoms that suggest possible Alzheimer's disease, meaning
the dementia could be due to another cause.
- A
patient has MCI or dementia with onset at an early age (<65).
- A
patient meets core clinical criteria for probable Alzheimer's disease with
typical age of onset.
- A
patient's dominant symptom is an unexplained change in behavior, such as
delusions and delirium, and an Alzheimer's disease diagnosis is being
considered.
No comments:
Post a Comment